ANA-975

• Description :

  ANA975, 5-amino-3-β -D-ribofuranosyl-3H-thiazolo[4,5-d]pyrimidin-2-one derivative, is an oral prodrug of the TLR-7 agonist Isatoribine (HY-13655A) . ANA975 is converted to Isatoribine via a combined mechanism of hydrolysis by esterases and oxidation by aldehyde oxidase. ANA975 can be used in the research of hepatitis C virus infection[1].

• UNSPSC :

  12352005

• Target :

  Aldehyde Oxidase (AO) ; Drug Derivative

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Infection

• Smiles :

  O=C1SC2=CN=C(N)N=C2N1[C@H]3[C@@H]([C@@H]([C@@H](CO)O3)OC(C)=O)OC(C)=O

• Molecular Formula :

  C14H16N4O7S

• Molecular Weight :

  384.36

• References & Citations :

  [1]Xiang AX, et al. Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26 (6-7) :635-40.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [847453-47-8]