K-975

• UNSPSC Description:

  K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

• Target Antigen:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/k-975.html

• Smiles:

  C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

• Molecular Weight:

  287.74

• References & Citations:

  [1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10(12):4399-4415.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2563855-03-6