K-975

• Description:

  K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

• UNSPSC:

  12352005

• Target:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/k-975.html

• Purity:

  99.89

• Solubility:

  DMSO : 220 mg/mL (ultrasonic)

• Smiles:

  C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

• Molecular Formula:

  C16H14ClNO2

• Molecular Weight:

  287.74

• References & Citations:

  [1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10 (12) :4399-4415.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2563855-03-6]