K-975

• Description :

  K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma[1].

• UNSPSC :

  12352005

• Target :

  YAP

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/k-975.html

• Purity :

  99.89

• Solubility :

  DMSO : 220 mg/mL (ultrasonic)

• Smiles :

  C=CC(NC1=CC=C(C)C(OC2=CC=C(Cl)C=C2)=C1)=O

• Molecular Formula :

  C16H14ClNO2

• Molecular Weight :

  287.74

• References & Citations :

  [1]Kaneda A, et, al. The novel potent TEAD inhibitor, K-975, inhibits YAP1/TAZ-TEAD protein-protein interactions and exerts an anti-tumor effect on malignant pleural mesothelioma. Am J Cancer Res. 2020 Dec 1;10 (12) :4399-4415.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2563855-03-6]