AChE-IN-62

• UNSPSC Description:

  AChE-IN-62 (Compound 1) is an effective mixed and selective acetylcholinesterase (AChE) inhibitor with an IC50 value of 0.421 μM. AChE-IN-62 exhibits excellent blood-brain barrier permeability and neuroprotective effects. Additionally, AChE-IN-62 can inhibit the aggregation of Aβ1-42 with an IC50 value of 44.64 μM. AChE-IN-62 is also an effective multi-target-directed ligand (MTDL) that can be utilized in the research of Alzheimer's disease[1].

• Target Antigen:

  Amyloid-β; Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ache-in-62.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CS(C1=CC=C2C(SC(NC(CN3CCN(C4=CC=CC=N4)CC3)=O)=N2)=C1)(=O)=O

• Molecular Weight:

  431.53

• References & Citations:

  [1]Mishra CB, et al. Multitarget action of Benzothiazole-piperazine small hybrid molecule against Alzheimer's disease: In silico, In vitro, and In vivo investigation. Biomed Pharmacother. Published online April 1, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported