BMS-751324

CAT: 0804-HY-18759Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18759Size:1 Each
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Description
BMS-751324 is a p38α MAPK inhibitor. BMS-751324 equips a precursor of carbamyl-methyl linkage, containing esters and phosphate functional groups derived from hydroxyphenylacetic acid (HPA) . BMS-751324 effectively inhibits foot swelling and LPS-induced TNFα production in an arthritic rat model[1].
CAS Number
[948842-66-8]
UNSPSC
12352005
Target
P38 MAPK; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bms-751324.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C(NC2CC2)=O)C=C1NC3=NC=NN4C3=C(C)C(C(N(C(OCOC(CC5=CC=C(OP(O)(O)=O)C=C5)=O)=O)CCC)=O)=C4
Molecular Formula
C32H35N6O10P
Molecular Weight
694.63
References & Citations
[1]Liu C, et al. Discovery of 4- (5- (cyclopropylcarbamoyl) -2-methylphenylamino) -5-methyl-N-propylpyrrolo [1, 2-f][1, 2, 4] triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases[J]. Journal of medicinal chemistry, 2010, 53 (18) : 6629-6639.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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