BMS-767778

• Description :

  BMS-767778 is a selective DPP4 inhibitor, with a Ki of 0.9 nM[1].

• UNSPSC :

  12352005

• Target :

  Dipeptidyl Peptidase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/bms-767778.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N(C)C)CN1CC2=NC(C)=C(CN)[C@]([C@]3=CC=C(Cl)C=C3Cl)=C2C1=O

• Molecular Formula :

  C19H20Cl2N4O2

• Molecular Weight :

  407.29

• References & Citations :

  [1]Pratik Devasthale, et al. Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa) -2- (3- (aminomethyl) -4- (2,4-dichlorophenyl) -2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6 (7H) -yl) -N, N-dimethylacetamide (BMS-767778) . J Med Chem . 2013 Sep 26;56 (18) :7343-57.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [915729-95-2]