AlF-PD-FAPI

• UNSPSC Description:

  AlF-PD-FAPI has affinity for FAP , with the IC50 of 0.13 nM, and shows a specific uptake, high internalized fraction, and low cellular efflux in vitro. AlF-PD-FAPI can be used as FAP-targeting tracer[1].

• Target Antigen:

  FAP

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/alf-pd-fapi.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]1(CC(F)(CN1C(CNC(C2=CC=NC3=CC=C(C=C32)OCCOCCOCCNC([C@@H](NC(CN4CCN(CCN(CC4)C5)CC(O[Al](F)OC5=O)=O)=O)CC(N[C@H](C(O)=O)CC(O)=O)=O)=O)=O)=O)F)C#N

• Molecular Weight:

  1050.92

• References & Citations:

  [1]Hui Zhou, et al. Synthesis and preclinical evaluation of novel 18F-labeled fibroblast activation protein tracers for positron emission tomography imaging of cancer-associated fibroblasts. European Journal of Medicinal Chemistry Volume 264, 15 January 2024, 115993

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported