FAPI-800CW

• Description:

  FAPI-800CW is a near-infrared (NIR) fluorescent-labeled fibroblast activation protein (FAP) inhibitor. FAPI-800CW shows specific uptake in inflamed paws in collagen-induced arthritis (CIA) model mice. FAPI-800CW can be used for in vivo molecular imaging of FAP expression in inflammatory diseases such as rheumatoid arthritis (RA) to monitor joint inflammation and disease activity[1].

• UNSPSC:

  12352005

• Target:

  FAP

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.40

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC(C[C@H]1C#N)(CN1C(CNC(C2=CC=NC3=C2C=C(C=C3)OCCCN4CCN(CC4)C(CCCCC[N+]5=C(/C=C/C6=C(/C(CCC6)=C/C=C7N(CCCCS(=O)([O-])=O)C8=C(C/7(C)C)C=C(S(=O)(O)=O)C=C8)OC9=CC=C(S(=O)(O)=O)C=C9)C(C)(C)C%10=CC(S(=O)(O)=O)=CC=C5%10)=O)=O)=O)F

• Molecular Formula:

  C70H80F2N8O17S4

• Molecular Weight:

  1471.68

• References & Citations:

  [1]Narain R, et al. Increased imaging ligand hydrophilicity and improved pharmacokinetic properties provides enhanced in vivo targeting of fibroblast activation protein. Npj Imaging. 2024 Aug 2;2 (1) :24.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported