FAPI-JNU

• Description :

  FAPI-JNU is a molecule targeting fibroblast activation protein (FAP) . FAPI-JNU specifically binds to FAP highly expressed in the tumor microenvironment, and uses radionuclides [68Ga]Ga or [177Lu]Lu to achieve tumor imaging diagnosis. [177Lu]Lu−FAPI−JNU can effectively target and inhibit tumor growth in tumor-bearing mice. FAPI-JNU is promising for research of FAP-positive tumors (such as various solid tumors) [1].

• UNSPSC :

  12352005

• Target :

  FAP

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer

• Smiles :

  O=C(CN(CCN(CC(N[C@H](C(N[C@H](C(NCCOCCOCCOCCOCC(N1CCN(CC1)CCCN(C2=CC=C(C3=C2)N=CC=C3C(NCC(N4CC(F)(C[C@]4(C#N)[H])F)=O)=O)C)=O)=O)CCCCNC(CCCC5=CC=C(C=C5)O)=O)=O)CCC(NCCOCCOCCOCCOCC(N6CCN(CC6)CCCN(C7=CC=C(C8=C7)N=CC=C8C(NCC(N9CC(F)(C[C@]9(C#N)[H])F)=O)=O)C)=O)=O)=O)CCN(CC%10)CC(O)=O)CCN%10CC(O)=O)O

• Molecular Formula :

  C107H153F4N23O26

• Molecular Weight :

  2253.49

• References & Citations :

  [1]Luo Y, et al. Rational Design and Preliminary Evaluation of a Radiopharmaceutical Targeting Fibroblast Activation Proteins [68Ga]Ga/[177Lu]Lu-FAPI-JNU for Tumor Imaging and Therapy. J Med Chem. 2025 Jun 26;68 (12) :12745-12755.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported