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NOTA-FAPI

CAT: 0804-HY-136641-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136641-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NOTA-FAPI is a fibroblast activation protein (FAP) inhibitor. NOTA-FAPI can be used as a probe for FAP-targeted tumour imaging. NOTA-FAPI has good tumour detection efficacy and excellent imaging quality[1][2][3].
CAS Number
[2374782-03-1]
UNSPSC
12352005
Target
FAP; Radionuclide-Drug Conjugates (RDCs)
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nota-fapi.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CC5(F)F)[C@@H](C5)C#N)=O
Molecular Formula
C36H47F2N9O8
Molecular Weight
771.81
References & Citations
[1]Wang S, et al. Clinical translational evaluation of Al18F-NOTA-FAPI for fibroblast activation protein-targeted tumour imaging. Eur J Nucl Med Mol Imaging. 2021 Dec;48 (13) :4259-4271. |[2]Guo YH, et al. Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma. Clin Nucl Med. 2021 Nov 1;46 (11) :929-930.|[3]Ge L, et al. Preclinical evaluation and pilot clinical study of [18F]AlF-NOTA-FAPI-04 for PET imaging of rheumatoid arthritis. Eur J Nucl Med Mol Imaging. 2022 Oct;49 (12) :4025-4036.|[4]Guo YH, et al. Comparison of 18F-AlF-NOTA-FAPI and 18F-FDG Imaging in a Patient With Gastric Signet-Ring Cell Carcinoma. Clin Nucl Med. 2021 Nov 1;46 (11) :929-930.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RDC Bifunctional Chelator

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