FAPI-46

CAT: 0804-HY-137331-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-137331-01Size:1 mg
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Description
FAPI-46 is a quinoline-based fibroblast activation protein (FAP) -targeted tracer. Use radioactivity FAPI-46 labeled with 68Ga or 177Lu can be used for tumor imaging in a variety of cancers and has higher tumor uptake rates and longer tumor accumulation[1][2].
CAS Number
[2374782-04-2]
UNSPSC
12352005
Target
FAP
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fapi-46.html
Concentration
10mM
Purity
99.02
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=NC(C=C2)=C1C=C2N(C)CCCN(CC3)CCN3C(CN(CCN(CC4)CC(O)=O)CCN(CCN4CC(O)=O)CC(O)=O)=O)NCC(N(CC5(F)F)[C@@H](C5)C#N)=O
Molecular Formula
C41H57F2N11O9
Molecular Weight
885.96
References & Citations
[1]Loktev A, et, al. Development of Fibroblast Activation Protein-Targeted Radiotracers with Improved Tumor Retention. J Nucl Med. 2019 Oct;60 (10) :1421-1429.|[2]Moon ES, et, al. Targeting fibroblast activation protein (FAP) : next generation PET radiotracers using squaramide coupled bifunctional DOTA and DATA 5m chelators. EJNMMI Radiopharm Chem. 2020 Jul 29;5 (1) :19.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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