FAPI-74

• Description:

  FAPI-74 is a PET (positron emission tomography) tracer targeting the fibroblast activation protein (FAP) . FAPI-74 can be used for FAP-positive tumor research[1][2].

• UNSPSC:

  12352005

• Target:

  FAP

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fapi-74.html

• Purity:

  99.84

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=NC(C=C2)=C1C=C2OCCCN(CC3)CCN3C(CN(CCN4CC(O)=O)CCN(CC4)CC(O)=O)=O)NCC(N(CCC5)[C@@H]5C#N)=O

• Molecular Formula:

  C36H49N9O8

• Molecular Weight:

  735.83

• References & Citations:

  [1]Uwe Haberkorn, et al. Fap inhibitor. Patent, WO2019154886A1.|[2]Giesel FL, et al. FAPI-74 PET/CT Using Either 18F-AlF or Cold-Kit 68Ga Labeling: Biodistribution, Radiation Dosimetry, and Tumor Delineation in Lung Cancer Patients. J Nucl Med. 2021 Feb;62 (2) :201-207. |[3]Liu Y, et al. Fibroblast activation protein targeted therapy using [177Lu]FAPI-46 compared with [225Ac]FAPI-46 in a pancreatic cancer model. Eur J Nucl Med Mol Imaging. 2022 Feb;49 (3) :871-880.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2374782-76-8]