COX-2/15-LOX/mPGES1-IN-1
CAT:
804-HY-162166
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
COX-2/15-LOX/mPGES1-IN-1
- UNSPSC Description: COX-2/15-LOX/mPGES1-IN-1 (Compound 2c) is an inhibitor of COX-2, 15-LOX, and mPGES-1 enzymes with IC50 values of 0.057, 2.39, and 2.8 μM, respectively. COX-2/15-LOX/mPGES1-IN-1 possesses anti-inflammatory activity and can inhibit rat paw edema in vivo experiments[1].
- Target Antigen: COX; Lipoxygenase
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-mpges1-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(N/N=C/C1=COC2=C(C=CC(OC)=C2)C1=O)OCC3=CC=CC=C3
- Molecular Weight: 352.34
- References & Citations: [1]Elzahhar PA, et al. Chromone-based small molecules for multistep shutdown of arachidonate pathway: Simultaneous inhibition of COX-2, 15-LOX and mPGES-1 enzymes. Eur J Med Chem. 2024 Jan 10;266:116138.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported