COX-2/15-LOX-IN-1

COX-2/15-LOX-IN-1

• CAS Number: 2413565-15-6
• UNSPSC Description: COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].
• Target Antigen: COX; Lipoxygenase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: S=C(NC1=CC=CC=C1)N/N=C(C)/CNC2=NC(N3C(SC)=NC4=CC=CC=C34)=CS2
• Molecular Weight: 467.63
• References & Citations: [1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported