COX-2/15-LOX-IN-4

• UNSPSC Description:

  COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-4 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS) with specific anti-inflammatory activity[1].

• Target Antigen:

  COX; Lipoxygenase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-15-lox-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC(C=C1)=CC=C1C2=NC3=C(C(CCCC4)=C4S3)C(NC5=CC=C(F)C=C5)=N2

• Molecular Weight:

  405.49

• References & Citations:

  [1]Elsayed S, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity. Eur J Med Chem. 2023 Aug 15;260:115724.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported