COX-2/15-LOX-IN-3

COX-2/15-LOX-IN-3

• UNSPSC Description: COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2/15-LOX with IC50s of 0.075 μM and 1.97 μM, respectively. COX-2/15-LOX-IN-3 can inhibit LPS-induced cell production of promoting cytokines (IL-6, ROS, and NO), with specific anti-inflammatory activity[1].
• Target Antigen: COX; Lipoxygenase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(OC)C(OC)=CC(C2=NC3=C(C(CCCC4)=C4S3)C(NC5=CC=C(F)C=C5)=N2)=C1
• Molecular Weight: 465.54
• References & Citations: [1]Elsayed S, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity. Eur J Med Chem. 2023 Aug 15;260:115724.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported