COX-2/15-LOX-IN-2

• UNSPSC Description:

  COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065 μM and 1.86 μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity[1].

• Target Antigen:

  COX; Lipoxygenase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-15-lox-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC(C=C1)=CC=C1C2=NC3=C(C(CCCC4)=C4S3)C(NNC5=C(C(CCCC6)=C6S7)C7=NC=N5)=N2

• Molecular Weight:

  514.66

• References & Citations:

  [1]Sara Elsayed, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity . Eur J Med Chem. 2023 Nov 15;260:115724.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported