COX-2/15-LOX-IN-2

COX-2/15-LOX-IN-2

• UNSPSC Description: COX-2/15-LOX-IN-2 is a potent dual COX-2 and 15-LOX inhibitor with IC50 values of 0.065 μM and 1.86 μM, respectively. COX-2/15-LOX-IN-2 has potent antioxidant activity[1].
• Target Antigen: COX; Lipoxygenase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C=C1)=CC=C1C2=NC3=C(C(CCCC4)=C4S3)C(NNC5=C(C(CCCC6)=C6S7)C7=NC=N5)=N2
• Molecular Weight: 514.66
• References & Citations: [1]Sara Elsayed, et al. Magic shotgun approach to anti-inflammatory pharmacotherapy: Synthesis of novel thienopyrimidine monomers/heterodimer as dual COX-2 and 15-LOX inhibitors endowed with potent antioxidant activity . Eur J Med Chem. 2023 Nov 15;260:115724.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported