COX-2/5-LOX-IN-1

COX-2/5-LOX-IN-1

• CAS Number: 2410384-50-6
• UNSPSC Description: COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively[1].
• Target Antigen: COX
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-5-lox-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C1=NN(C(C2=CC=C(S2)Cl)=C1)C3=CC=C(C=C3)S(N)(=O)=O)=O
• Molecular Weight: 383.83
• References & Citations: [1]Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported