COX-2/15-LOX-IN-6

COX-2/15-LOX-IN-6

• UNSPSC Description: COX-2/15-LOX-IN-6 (Compound 5l) is the dual inhibitor for COX-2 and 15-LOX, with IC50 of 0.201 μM and 11.723 μM. COX-2/15-LOX-IN-6 inhibits the expression of PGE, TNF-α, IL-6 and iNOS in serum, and exhibits anti-inflammatory effect in Carrageenan (HY-125474)-induced rats edema model[1].
• Target Antigen: COX; Lipoxygenase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-in-6.html
• Smiles: COC1=CC=C(C2=NN(C3=NC(C4=CC=C(OC)C=C4)=CS3)C(C5=CC6=C(C=CC(OC)=C6)N=C5OC)C2)C=C1
• Molecular Weight: 552.64
• References & Citations: [1]Hegazy ME, et al., Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study. Bioorg Chem. 2024 Apr;145:107244.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported