COX-2/15-LOX-IN-5

• UNSPSC Description:

  COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities[1].

• Target Antigen:

  COX; Lipoxygenase; NF-κB

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-15-lox-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)NC(CSC2=N/C(C(N2C3=CC=CC=C3)=O)=C\C4=CC=CC=C4)=O

• Molecular Weight:

  443.52

• References & Citations:

  [1]Osman NA, et al. Dual COX-2 and 15-LOX inhibition study of novel 4-arylidine-2-mercapto-1-phenyl-1H-imidazolidin-5(4H)-ones: Design, synthesis, docking, and anti-inflammatory activity. Arch Pharm (Weinheim). 2024 Feb 5:e2300615.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  443790-30-5