COX-2/15-LOX-IN-5

COX-2/15-LOX-IN-5

• CAS Number: 443790-30-5
• UNSPSC Description: COX-2/15-LOX-IN-5 (Compound 4f) is a dual inhibitor of COX-2/15-LOX. COX-2/15-LOX-IN-5 attenuates increased NF-κB activation in RAW 264.7 macrophages mediated by lipopolysaccharide (HY-D1056). COX-2/15-LOX-IN-5 has anti-inflammatory and antioxidant activities[1].
• Target Antigen: COX; Lipoxygenase; NF-κB
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-15-lox-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C(C=C1)NC(CSC2=N/C(C(N2C3=CC=CC=C3)=O)=C\C4=CC=CC=C4)=O
• Molecular Weight: 443.52
• References & Citations: [1]Osman NA, et al. Dual COX-2 and 15-LOX inhibition study of novel 4-arylidine-2-mercapto-1-phenyl-1H-imidazolidin-5(4H)-ones: Design, synthesis, docking, and anti-inflammatory activity. Arch Pharm (Weinheim). 2024 Feb 5:e2300615.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported