Products for Research Use Only
RegisterLogin

Axl-IN-18

CAT: 0804-HY-162103Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162103Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM) . Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model[1].
CAS Number
3040329-68-5
UNSPSC
12352005
Target
Apoptosis; TAM Receptor
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
Molecular Formula
C32H26FN5O4
Molecular Weight
563.58
References & Citations
[1]Linsheng Zhuo, et al. Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy. Eur J Med Chem. 2023 Dec 30:265:116090.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-147578Axl-IN-11
HY-153441AXL-IN-15
HY-144708Axl-IN-4
HY-147579Axl-IN-12
HY-151904-01AXL-IN-13
HY-162085Axl-IN-17
HY-147576Axl-IN-9
HY-147577Axl-IN-10
HY-152075AXL-IN-14
HY-147574Axl-IN-7

Alternative Products

CatalogName
T209083-01Axl-IN-18
101-M222Axl
209692-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) discontinued
MBS6407952-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (Biotin)
MBS6407953-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (FITC)
MBS6407951-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (APC)
MBS6407960-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (PE)
MBS6407954-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (HRP)
MBS6407950-01AXL (AXL Oncogene, AXL Receptor Tyrosine Kinase, AXL Transforming Gene, JTK11, UFO) (AP)
SIPL664Ra01-01Recombinant AXL Receptor Tyrosine Kinase (AXL)

Popular Products