Axl-IN-18

Axl-IN-18

• CAS Number: 3040329-68-5
• UNSPSC Description: Axl-IN-18 (compound 25c) is a potent and selective type II AXL inhibitor. Axl-IN-18 shows excellent AXL inhibitory activity (IC50=1.1 nM) and 343-fold selectivity over the highly homologous kinase MET in biochemical assays (IC50=377 nM). Axl-IN-18 significantly inhibits AXL-driven cell proliferation, dose-dependently suppresses 4T1 cell migration and invasion, and induces apoptosis. Axl-IN-18 shows noticeable antitumor efficacy in a BaF3/TEL-AXL xenograft model[1].
• Target Antigen: Apoptosis; TAM Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/axl-in-18.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OC)=C5)C5=NC=N4)C=C3)N=CC=C2N(C)C=C1C6=CC=CC(C)=C6
• Molecular Weight: 563.58
• References & Citations: [1]Linsheng Zhuo, et al. Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy. Eur J Med Chem. 2023 Dec 30:265:116090.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported