Axl-IN-17

Axl-IN-17

• CAS Number: 3048409-80-6
• UNSPSC Description: Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC50 value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy[1].
• Target Antigen: TAM Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/axl-in-17.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)N1C=C(C2=CC=C(F)C=C2)C(C3=C(NC4=CC(F)=C(C5=C(N)N=CC(C6=CN(C)N=C6)=C5)C=C4)N=CC=C31)=O
• Molecular Weight: 563.60
• References & Citations: [1]Lan Y,et al., Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy. Eur J Med Chem. 2024 Feb 5;265:116045.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported