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Axl-IN-17

CAT: 0804-HY-162085Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162085Size:1 Each
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Description
Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC50 value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy[1].
CAS Number
3048409-80-6
UNSPSC
12352005
Target
TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-17.html
Solubility
10 mM in DMSO
Smiles
CC(C)N1C=C(C2=CC=C(F)C=C2)C(C3=C(NC4=CC(F)=C(C5=C(N)N=CC(C6=CN(C)N=C6)=C5)C=C4)N=CC=C31)=O
Molecular Formula
C32H27F2N7O
Molecular Weight
563.60
References & Citations
[1]Lan Y, et al., Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy. Eur J Med Chem. 2024 Feb 5;265:116045.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl; Mer; Tyro3

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