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Axl-IN-18

CAT: 0931-T209083-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209083-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3040329-68-5
Target
TAM Receptor, Apoptosis
Related Pathways
Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
Axl-IN-18 (compound 25c) serves as a potent and selective Type II AXL inhibitor. It exhibits remarkable AXL inhibitory activity with an IC50 of 1.1 nM and is 343 times more selective for AXL compared to the closely related kinase MET, which has an IC50 of 377 nM. Axl-IN-18 significantly inhibits cell proliferation driven by AXL, reduces 4T1 cell migration and invasion in a dose-dependent manner, and induces apoptosis. In the BaF3/TEL-AXL xenograft model, Axl-IN-18 demonstrates significant antitumor efficacy.
Smiles
O=C1C(=CN(C=2C=CN=C(NC3=CC=C(OC4=NC=NC=5C=C(OC)C(OC)=CC45)C(F)=C3)C12)C)C=6C=CC=C(C6)C
Molecular Formula
C32H26FN5O4
Molecular Weight
563.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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