Axl-IN-8

Axl-IN-8

• CAS Number: 2231424-62-5
• UNSPSC Description: Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of [1].
• Target Antigen: c-Met/HGFR; TAM Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/axl-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=CN(C=C(C4=O)C5=CC=C(C=C5)F)CC6CCOCC6)=O
• Molecular Weight: 552.60
• References & Citations: [1]Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported