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Axl-IN-8

CAT: 0804-HY-147575Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147575Size:1 Each
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Description
Axl-IN-8 (NO.1) is a potent AXL inhibitor, with an IC50 of c-MET, with an IC50 of 1-10 nM. Axl-IN-8 shows anti-proliferative activity against BaF3/TEL-AXL, MKN45, and EBC-1 cells, with IC50 values of [1].
CAS Number
2231424-62-5
UNSPSC
12352005
Target
C-Met/HGFR; TAM Receptor
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/axl-in-8.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C2=C1N=CN=C2N)C3=CC=C(C=C3)NC(C4=CN(C=C(C4=O)C5=CC=C(C=C5)F)CC6CCOCC6)=O
Molecular Formula
C31H29FN6O3
Molecular Weight
552.60
References & Citations
[1]Duan Wenhu, et al. Compound having axl inhibitory activity, preparation method therefor and use thereof. WO2018121228A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Axl

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