HDAC-IN-68

• UNSPSC Description:

  HDAC-IN-68 (Compound 29) is a potent HDAC inhibitor that disrupts microtubule structure and inhibits tumor growth. HDAC-IN-68 significantly inhibits class I HDACs (HDAC1, HDAC2, HDAC3) with IC50 values of 5.1, 11.5 and 8.8 nM, respectively[1].

• Target Antigen:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac-in-68.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1C2=C(OC)N=CC=C2)NC3=C1N=C(C4=CC=C(OCC)N=C4)N=C3C(NCC5=CC=C(C=C5)C(NO)=O)=O

• Molecular Weight:

  556.53

• References & Citations:

  [1]Tseng YW, et al. Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition. Eur J Med Chem. 2023 Dec 15;265:116042.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported