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HDAC-IN-68

CAT: 0804-HY-162086Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162086Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-68 (Compound 29) is a potent HDAC inhibitor that disrupts microtubule structure and inhibits tumor growth. HDAC-IN-68 significantly inhibits class I HDACs (HDAC1, HDAC2, HDAC3) with IC50 values of 5.1, 11.5 and 8.8 nM, respectively[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-68.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=C(OC)N=CC=C2)NC3=C1N=C(C4=CC=C(OCC)N=C4)N=C3C(NCC5=CC=C(C=C5)C(NO)=O)=O
Molecular Formula
C27H24N8O6
Molecular Weight
556.53
References & Citations
[1]Tseng YW, et al. Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition. Eur J Med Chem. 2023 Dec 15;265:116042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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