Antimalarial agent 37

• Description:

  Antimalarial agent 37 (compound 33) is a selective inhibitor against Type II kinase with antiplasmodial activity. Antimalarial agent 37 exhibited cytotoxicity and selectivity towards cancer cells HepG2 and MCF 7[1].

• UNSPSC:

  12352005

• Target:

  Ephrin Receptor; Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antimalarial-agent-37.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCN1CCN(CC1)CC2=CC=C(C=C2C(F)(F)F)NC(C3=CC(NC(C4=CC(C5=CC=CS5)=CN=C4)=O)=CC(C(F)(F)F)=C3)=O

• Molecular Formula:

  C32H29F6N5O2S

• Molecular Weight:

  661.66

• References & Citations:

  [1]Wang L, et al., Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 12. doi: 10.1021/acs.jmedchem.3c02046

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2982633-16-7]