Antimalarial agent 33

CAT: 0804-HY-155354-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155354-01Size:5 mg
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Description
Antimalarial agent 33 (compound 5g) has antiplasmodial activity against erythrocytic and hepatic stages of Plasmodium with an EC50 of 1.1 μM for K1 P. falciparum strain. Antimalarial agent 33 demonstrats enhanced microsomal stability (T1/2=29 min) . Antimalarial agent 33 has no significant cytotoxicity against primary hepatocytes[1].
CAS Number
[9007-83-4]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-33.html
Purity
99.13
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=C(C2=CC(N=C(NC3CCC3)NC4=O)=C4S2)C=C1
Molecular Formula
C17H17N3OS
Molecular Weight
311.40
References & Citations
[1]Prisca Lagardère, et al. Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability. Eur J Med Chem. 2023 Dec 5:261:115873.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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