Antimalarial agent 12

CAT: 0804-HY-143487Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-143487Size:1 Each
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Description
Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM) . Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli[1].
CAS Number
[2715225-58-2]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/antimalarial-agent-12.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6
Molecular Formula
C26H18BrClN2O2
Molecular Weight
505.79
References & Citations
[1]Hanan Almolhim, et al. Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro. ACS Med Chem Lett. 2022 Feb 24;13 (3) :371-376.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium

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