Antimalarial agent 12

• Description:

  Antimalarial agent 12 (compound R-3b) is a potent antimalarial agent. Antimalarial agent 12 shows growth inhibition on P. falciparum Dd2 Strain (EC50=155 nM), 3D7 strain (EC50=136 nM) . Antimalarial agent 12 has CC50 values of 10,000 to 50,000 nM for HEK-293 and hPHep cell lines. Antimalarial agent 12 has a MIC of >250,000 nM for Escherichia coli[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antimalarial-agent-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC2=CC(Br)=CC=C2O1)N([C@@H]3C4=CC=C(Cl)C=C4)CCC5=C3NC6=C5C=CC=C6

• Molecular Formula:

  C26H18BrClN2O2

• Molecular Weight:

  505.79

• References & Citations:

  [1]Hanan Almolhim, et al. Enantiopure Benzofuran-2-carboxamides of 1-Aryltetrahydro-β-carbolines Are Potent Antimalarials In Vitro. ACS Med Chem Lett. 2022 Feb 24;13 (3) :371-376.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Plasmodium

• CAS Number:

  [2715225-58-2]