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Antimalarial agent 41

CAT: 0931-T210205-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T210205-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
PI4K|||Potassium Channel
Related Pathways
Membrane transporter/Ion channel|||PI3K/Akt/mTOR signaling
Bioactivity
Antimalarial agent 41 (Compound 17) exhibits antimalarial activity by inhibiting the malaria parasite Plasmodium falciparum, with IC50 values of 40 nM for NF54 strain and 76 nM for K1 strain. This compound acts as an inhibitor of P. falciparum phosphatidylinositol-4-kinase ? (PfPI4K) and hERG channels, with IC50 values of 53 nM and 3 ?M, respectively. Additionally, Antimalarial agent 41 shows cytotoxicity against CHO cells, with an IC50 of 34 ?M. It can improve malaria infections and demonstrates favorable pharmacokinetic properties in mouse models.
Molecular Formula
C19H18F3N5
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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