Antimalarial agent 36

• Description:

  Antimalarial agent 36 (compound 1) is an antimalarial agent, with the EC50s of 58 nM and 42 nM, for Dd2 and 3D7, respectively. Antimalarial agent 36 targets EphA2[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/antimalarial-agent-36.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(C2=CC=CS2)=CN=C1)NC3=CC(Cl)=CC(C(NC4=CC=C(C(C(F)(F)F)=C4)CN5CCN(CC5)CC)=O)=C3

• Molecular Formula:

  C31H29ClF3N5O2S

• Molecular Weight:

  628.11

• References & Citations:

  [1]Wang L, et al. Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 Jan 25;67 (2) :1460-1480.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2982633-03-2]