MK-0668

• Description :

  MK-0668 is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats[1].

• UNSPSC :

  12352005

• Target :

  Integrin

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mk-0668.html

• Smiles :

  O=C(O)[C@H](CC1=CC=C(NC(C2=C(Cl)C=NC=C2Cl)=O)C=C1)NC([C@H]3N(S(=O)(C4=CC=CC(C#N)=C4)=O)C[C@H](NC5CCC5)C3)=O

• Molecular Formula :

  C31H30Cl2N6O6S

• Molecular Weight :

  685.58

• References & Citations :

  [1]Discovery of N-{N-[ (3-Cyanophenyl) sulfonyl]-4 (R) -cyclobutylamino- (l) -prolyl}-4-[ (3′,5′-dichloroisonicotinoyl) amino]- (l) -phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4 J. Med. Chem., 2009, 52 (11), pp 3449-3452

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [865110-07-2]