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MK-0668

CAT: 0804-HY-12159Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12159Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-0668 is an amino acid-based, potent antagonist of unactivated VLA-4, with an IC50) of 0.13 nM in human whole blood. And MK-0668 exhibits IC50s of 0.19 nM in dogs, 0.21 nM in rhesus monkeys, and 0.4 nM in rats[1].
CAS Number
[865110-07-2]
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/mk-0668.html
Smiles
O=C(O)[C@H](CC1=CC=C(NC(C2=C(Cl)C=NC=C2Cl)=O)C=C1)NC([C@H]3N(S(=O)(C4=CC=CC(C#N)=C4)=O)C[C@H](NC5CCC5)C3)=O
Molecular Formula
C31H30Cl2N6O6S
Molecular Weight
685.58
References & Citations
[1]Discovery of N-{N-[ (3-Cyanophenyl) sulfonyl]-4 (R) -cyclobutylamino- (l) -prolyl}-4-[ (3′,5′-dichloroisonicotinoyl) amino]- (l) -phenylalanine (MK-0668), an Extremely Potent and Orally Active Antagonist of Very Late Antigen-4 J. Med. Chem., 2009, 52 (11), pp 3449-3452
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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