GSPT1 degrader-1

GSPT1 degrader-1

• UNSPSC Description: GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis[1].
• Target Antigen: Apoptosis; Molecular Glues
• Type: Reference compound
• Related Pathways: Apoptosis;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/gspt1-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(CN(C)CCOC)C=C(NC(CCC2=CC=C3CN(C4CCC(NC4=O)=O)C(C3=C2)=O)=O)C=C1Cl
• Molecular Weight: 541.04
• References & Citations: [1]Wei Y, et al. Discovery of new Lenalidomide derivatives as potent and selective GSPT1 degraders. Eur J Med Chem. 2023 Oct 5;258:115580.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported