GSPT1 degrader-1

• UNSPSC Description:

  GSPT1 degrader-1 (compound 9q) is a potent degrader of G1 to S phase transition 1 (GSPT1) via ubiquitin-proteasome system, serves as one of Molecular Glues. GSPT1 degrader-1 also induces cell G0/G1 phase arrest and apoptosis[1].

• Target Antigen:

  Apoptosis; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gspt1-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(CN(C)CCOC)C=C(NC(CCC2=CC=C3CN(C4CCC(NC4=O)=O)C(C3=C2)=O)=O)C=C1Cl

• Molecular Weight:

  541.04

• References & Citations:

  [1]Wei Y, et al. Discovery of new Lenalidomide derivatives as potent and selective GSPT1 degraders. Eur J Med Chem. 2023 Oct 5;258:115580.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported