HDAC-IN-67

CAT: 0804-HY-157385Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-157385Size:1 Each
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Description
HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC50 values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity[1].
CAS Number
[2821923-75-3]
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-67.html
Solubility
10 mM in DMSO
Smiles
ONC(CCCCCCC(N1CCN(CC1)CC([C@@H]2CC[C@](C=C)(C)[C@H](C(CN3N=CC=C3)=C)C2)=C)=O)=O
Molecular Formula
C30H47N5O3
Molecular Weight
525.73
References & Citations
[1]Gao Y, et al., Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2195991.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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