HDAC6-IN-67

CAT: 0804-HY-178351Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178351Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-67 is a selective HDAC6 inhibitor (IC50 = 17.15 nM) that exhibits 19-fold selectivity over HDAC1. HDAC6-IN-67 selectively inhibits HDAC6 by interacting with Ser531 and His614. HDAC6-IN-67 induces apoptosis by inducing the cleavage of caspases 9, 8, 3, and PARP, upregulating Bax expression, and downregulating Bcl-2 expression. HDAC6-IN-67 effectively induces the acetylation of α-tubulin, without affecting histone H3 acetylation in MCF-7/ADR cells. HDAC6-IN-67 can be used for the study of breast cancer[1].
CAS Number
[2196247-20-6]
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; HDAC; Microtubule/Tubulin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=NC2=C(C(N1CC3=CC=C(C=C3)C(NO)=O)=O)C=CC=C2
Molecular Formula
C17H15N3O3
Molecular Weight
309.32
References & Citations
[1]Gupta SK, et al. Design, synthesis, and biological evaluation of quinazolin-4-one-based selective HDAC6 inhibitors targeting serine 531, histidine 614 residues, and the L1 and L2 loop. Eur J Med Chem. 2025 Dec 15;300:118184.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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