11β-HSD2-IN-1

11β-HSD2-IN-1

• UNSPSC Description: 11β-HSD2-IN-1 (compound CDSN) is a potent inhibitor of 11β-HSD2, inhibiting the metabolism of Cholestane-3β,5α,6β-triol (CT) in cells by 11β-HSD2 into the tumor promoter, carcinosterone. 11β-HSD2-IN-1 inhibits testosterone biosynthesis, thereby inhibiting MCF-7 cell proliferation. 11β-HSD2-IN-1 has immune activity and antiviral infection effects[1].
• Target Antigen: 11β-HSD
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/11β-hsd2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@@H](O)[C@@]4(O)C[C@@H](S(=O)(O)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
• Molecular Weight: 484.73
• References & Citations: [1]de Médina P et al. Chemical synthesis and biochemical properties of cholestane-5α,6β-diol-3-sulfonate: A non-hydrolysable analogue of cholestane-5α,6β-diol-3β-sulfate. J Steroid Biochem Mol Biol. 2023 Nov;234:106396.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported