TrxR-IN-6

• UNSPSC Description:

  TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis[1].

• Target Antigen:

  Apoptosis; TrxR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/trxr-in-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C([As]2SCCCS2)C=C1)C(Cl)Cl

• Molecular Weight:

  384.18

• References & Citations:

  [1]She W et al. Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy. Biochem Pharmacol. 2023 Nov 4;218:115908.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032446-53-7