TrxR-IN-6

TrxR-IN-6

• CAS Number: 3032446-53-7
• UNSPSC Description: TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis[1].
• Target Antigen: Apoptosis; TrxR
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/trxr-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC1=CC=C([As]2SCCCS2)C=C1)C(Cl)Cl
• Molecular Weight: 384.18
• References & Citations: [1]She W et al. Discovery of novel organoarsenicals as robust thioredoxin reductase inhibitors for oxidative stress mediated cancer therapy. Biochem Pharmacol. 2023 Nov 4;218:115908.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported