6,6′-Dihydroxythiobinupharidine

• UNSPSC Description:

  6,6′-Dihydroxythiobinupharidine is a cysteine proteases inhibitor. 6,6′-Dihydroxythiobinupharidine can enhance DNA cleavage mediated by human topoisomerase IIα and IIβ ~8-fold and ~3-fold, respectively[1][2].

• Target Antigen:

  Cathepsin

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/6-6-dihydroxythiobinupharidine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]12[C@@H](CC[C@H](N1[C@@H](O)[C@]3(CS[C@]4(C3)CC[C@@]([C@@H](CC[C@H]5C6=COC=C6)C)(N5[C@@H]4O)[H])CC2)C7=COC=C7)C

• Molecular Weight:

  526.73

• References & Citations:

  [1]Yamahara J, et al. Potent immunosuppressive principles, dimeric sesquiterpene thioalkaloids, isolated from nupharis rhizoma, the rhizoma of Nuphar pumilum (nymphaeaceae): structure-requirement of nuphar-alkaloid for immunosuppressive activity. Biol Pharm Bull. 1996;19(9):1241-1243.|[2]Dalvie ED, et al. 6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases. Bioorg Med Chem Lett. 2019;29(15):1881-1885.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  30343-70-5