TrxR-IN-3

TrxR-IN-3

• CAS Number: 2445565-58-0
• UNSPSC Description: TrxR-IN-3 (Compound 2c) is a potent inhibitor of TrxR. TrxR-IN-3 exhibits potent antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and resulted in marked apoptosis by regulating apoptosis-related proteins expressed in the breast cancer cells. TrxR-IN-3 also triggers the formation of autophagosomes and autolysosomes by promoting the expression of LC3-II and Beclin-1 and diminishing the expression of LC3-I and p62 proteins[1].
• Target Antigen: TrxR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trxr-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C=CCC/C1=C\C2=CC=C(OC(F)(F)F)C=C2
• Molecular Weight: 268.23
• References & Citations: [1]Qian J, et al. Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy. Eur J Med Chem. 2020 Oct 15;204:112610.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported