TrxR-IN-5

• UNSPSC Description:

  TrxR-IN-5 (compound 4f) is a potent TrxR (thioredoxin reductase) inhibitor, with an IC50 of 0.16 μM. TrxR-IN-5 increases the levels of ROS, thus leading to potent antiproliferative effects. TrxR-IN-5 exhibits prominent anticacer and anti-metastasis effects[1].

• Target Antigen:

  Reactive Oxygen Species

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trxr-in-5.html

• Solubility:

  DMSO : 50 mg/mL (ultrasonic;heat to 60°C)

• Smiles:

  O=C1C=CCC/C1=C/C2=CC=C(OC3=CC=C(/C=C4CCC=CC\4=O)C=C3)C=C2

• Molecular Weight:

  382.45

• References & Citations:

  [1]Meng C, et al. Efficacy of novel methylenecyclohexenone derivatives as TrxR inhibitors in suppressing the proliferation and metastasis of human cancer cells. Bioorg Chem. 2020 Dec;105:104360.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported