TrxR-IN-4

TrxR-IN-4

• CAS Number: 2414906-32-2
• UNSPSC Description: TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level[1].
• Target Antigen: TrxR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/trxr-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: FC(C=C1)=CC=C1[C@@H]2[N]3=CC(C=CC=C4)=C4[O-][Au+3]35[O-]C6=CC=CC=C6C=[N]5[C@H]2C7=CC=C(F)C=C7.F[P-](F)(F)(F)(F)F
• Molecular Weight: 796.40
• References & Citations: [1]Bian M, et al. Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity. Eur J Med Chem. 2020 May 1;193:112234.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported