TrxR-IN-4

• UNSPSC Description:

  TrxR-IN-4 (Compound 1b) is a potent inhibitor of TrxR. TrxR-IN-4 induces HepG2 cells apoptosis by activating the endoplasmic reticulum stress (ERS). TrxR-IN-4 improves the CCl4-induced liver damage in vivo by down-regulation of TrxR expression and inflammation level[1].

• Target Antigen:

  TrxR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trxr-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(C=C1)=CC=C1[C@@H]2[N]3=CC(C=CC=C4)=C4[O-][Au+3]35[O-]C6=CC=CC=C6C=[N]5[C@H]2C7=CC=C(F)C=C7.F[P-](F)(F)(F)(F)F

• Molecular Weight:

  796.40

• References & Citations:

  [1]Bian M, et al. Synthesis and biological evaluation of gold(III) Schiff base complexes for the treatment of hepatocellular carcinoma through attenuating TrxR activity. Eur J Med Chem. 2020 May 1;193:112234.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2414906-32-2