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CB1R/AMPK modulator 1

CAT: 0804-HY-155967Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155967Size:1 Each
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Description
CB1R/AMPK modulator 1 (Compound 38-S) is an orally active CB1R/AMPK modulator, with an Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. CB1R/AMPK modulator 1 activates AMPK. CB1R/AMPK modulator 1 reduces food intake and body weight, and improves glucose tolerance and insulin sensitivity[1].
CAS Number
2711012-08-5
UNSPSC
12352005
Target
AMPK; Cannabinoid Receptor
Type
Reference compound
Related Pathways
Epigenetics; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cb1r-ampk-modulator-1.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC=C(C=C1)C2=NN(C[C@@H]2C3=CC=CC=C3)C(/N=C(N)/NC(C)=O)=N/S(=O)(C4=CC=C(C=C4)Cl)=O
Molecular Formula
C25H22Cl2N6O3S
Molecular Weight
557.45
References & Citations
[1]Dvorácskó S, et al. Cannabinoformins: Designing Biguanide-Embedded, Orally Available, Peripherally Selective Cannabinoid-1 Receptor Antagonists for Metabolic Syndrome Disorders. J Med Chem. 2023 Aug 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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