AMPA receptor modulator-1

• UNSPSC Description:

  AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5)[1].

• Target Antigen:

  iGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/AMPA_Receptor_Modulator.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(C2=CC(C)=C(NC(C3)=O)C3=C2)C(OC(F)(F)F)=CC=C1

• Molecular Weight:

  341.71

• References & Citations:

  [1]Ravula S, et al. Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8. ACS Med Chem Lett. 2018 Jul 13;9(8):821-826.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2036074-41-4