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AMPA receptor modulator-1

CAT: 0804-HY-112699Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112699Size:1 mg
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Description
AMPA receptor modulator-1 is a potent, orally active and selective AMPAR regulatory protein TARP γ-8 negative modulator with a pIC50 of 9.7, more selective over GluA1/γ-2 (pIC50=5) [1].
CAS Number
2036074-41-4
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AMPA_Receptor_Modulator.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C2=CC(C)=C(NC(C3)=O)C3=C2)C(OC(F)(F)F)=CC=C1
Molecular Formula
C16H11ClF3NO2
Molecular Weight
341.71
References & Citations
[1]Ravula S, et al. Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8. ACS Med Chem Lett. 2018 Jul 13;9 (8) :821-826.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor

Chemical Information

AMPA Receptor Modulator-1
CAS Number2036074-41-4
PubChem CID122655505
IUPAC Name5-[2-chloro-6-(trifluoromethoxy)phenyl]-7-methyl-1,3-dihydroindol-2-one
Molecular FormulaC16H11ClF3NO2
Molecular Weight341.71
XLogP4.6
Topological Polar Surface Area38.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity459
SMILES
CC1=CC(=CC2=C1NC(=O)C2)C3=C(C=CC=C3Cl)OC(F)(F)F
InChI
InChI=1S/C16H11ClF3NO2/c1-8-5-9(6-10-7-13(22)21-15(8)10)14-11(17)3-2-4-12(14)23-16(18,19)20/h2-6H,7H2,1H3,(H,21,22)
InChIKey
AYAICAKEBFTALD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AMPA Receptor Modulator-1
CAS: 2036074-41-4
CID: 122655505
Formula: C16H11ClF3NO2
MW: 341.71
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight341.71
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass341.0430408
Monoisotopic Mass341.0430408
Topological Polar Surface Area38.3 Ų
Heavy Atom Count23
Formal Charge0
Complexity459
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

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MBS3844112-01AMPA Receptor Modulator-1
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A19659-50AMPA Receptor Modulator-1 50mg
A19659-5AMPA Receptor Modulator-1 5mg
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