CB1R agonist 1

• Description:

  CB1R agonist 1 (Compound '1350') is a potent full agonist of the cannabinoid-1 receptor (CB1R), with a Ki value of 0.95 nM. CB1R agonist 1 exhibits significant pain-reducing effects in multiple pain models, including acute heat pain, inflammatory pain, and neuropathic pain[1].

• UNSPSC:

  12352211

• Target:

  Cannabinoid Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease; Inflammation/Immunology

• Smiles:

  COC([C@@](NC(C1=NN(C(C)=C1)C2=CC(C(F)(F)F)=CC=C2)=O)(C3=CC=CS3)C)=O

• Molecular Formula:

  C20H18F3N3O3S

• Molecular Weight:

  437.44

• References & Citations:

  [1]Tummino TA, et al. Virtual library docking for cannabinoid-1 receptor agonists with reduced side effects. Nat Commun. 2025 Mar 6;16 (1) :2237.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CB1