CB1R antagonist 2

• Target :

  P38 MAPK|||Cannabinoid Receptor|||NF-?B

• Related Pathways :

  MAPK|||GPCR/G Protein|||NF-?B

• Bioactivity :

  CB1R antagonist 2 (Compound 11g) functions as an antagonist of the cannabinoid receptor 1 (CB1R), inhibiting the MAPK/NF-?B signaling pathway and exhibiting anti-inflammatory properties. In RAW264.7 cells, it suppresses LPS-induced expression of IL-6, IL-1?, and TNF-?. In murine models, it improves OVA-induced allergic rhinitis.

• Molecular Formula :

  C24H26N4O

• Molecular Weight :

  386.49

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C