CB1R Allosteric modulator 4

• Description :

  CB1R Allosteric modulator 4 is a positive allosteric modulator of cannabinoid type-1 (CB1R) with good biological activity. CB1R Allosteric modulator 4 inhibits cAMP production and shows robust activity in β-arrestin-2 recruitment[1].

• UNSPSC :

  12352005

• Target :

  Cannabinoid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/cb1r-allosteric-modulator-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=[N+](CC(C1=NC=CS1)C2=C(C3=CC=CC=C3)NC4=C2C=CC(C)=C4)[O-]

• Molecular Formula :

  C20H17N3O2S

• Molecular Weight :

  363.43

• References & Citations :

  [1]Schaffer PC, et al. Focused structure-activity relationship profiling around the 2-phenylindole scaffold of a cannabinoid type-1 receptor agonist-positive allosteric modulator: site-III aromatic-ring congeners with enhanced activity and solubility. Bioorg Med Chem. 2020 Nov 1;28 (21) :115727.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  CB1

• CAS Number :

  [2633686-53-8]