CB1R Allosteric modulator 5

• Description:

  CB1R Allosteric modulator 5 (compound 3) is a selective, and blood-brain barrier (BBB) permeable Cannabinoid receptor type 1 allosteric modulator with a pIC50 of 6.89. CB1R Allosteric modulator 5 attenuates both cocaine-seeking behavior specific to cue-induced reinstatement and cocaine-induced behavioral sensitization without altering locomotor activity[1].

• UNSPSC:

  12352005

• Target:

  Cannabinoid Receptor

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Purity:

  98.35

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C (NC2=CC=C (Cl) C=C2) =C (NCCC3=CC (Cl) =CC=C3) C1=O

• Molecular Formula:

  C18H14Cl2N2O2

• Molecular Weight:

  361.22

• References & Citations:

  [1]Nguyen T, et al. Development of Squaramides as Allosteric Modulators of the CB1 Receptor: Synthesis, Computational Studies, Biological Characterization, and Effects against Cocaine-Induced Behavioral Sensitization and Reinstatement in Rats. J Med Chem. 2025 Apr 24;68 (8) :8694-8712.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3019958-44-9