CB1R antagonist 2

• Description:

  CB1R antagonist 2 (Compound 11g) is the antagonist for cannabinoid receptor 1 (CB1R), that inhibits MAPK/NF-κB signaling pathway and exhibits anti-inflammatory activity. CB1R antagonist 2 inhibits LPS (HY-D1056) -induced IL-6, IL-1β and TNF-α expressions in RAW264.7. CB1R antagonist 2 ameliorates OVA-induced allergic rhinitis in mouse models[1].

• UNSPSC:

  12352005

• Target:

  Cannabinoid Receptor; NF-κB; p38 MAPK

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(C1=NN(C2=CC=CC=C2)C(C3CCCCC3)=N1)N(C)/C=C\C4=CC=CC=C4

• Molecular Formula:

  C24H26N4O

• Molecular Weight:

  386.49

• References & Citations:

  [1]Wang L, et al., Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist. Eur J Med Chem. 2025 Feb 27;289:117461.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported