A3AR agonist 2

• Description:

  A3AR agonist 2 (Compound 19) a selective A3AR agonist (Ki: 22.1 nM) . A3AR agonist 2 stimulates β-arrestin2 recruitment, with EC50 value of 4.36 nM. A3AR agonist 2 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions[1]. A3AR agonist 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Target:

  Adenosine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/a3ar-agonist-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CNC ([C@]12[C@@H] (O) [C@@H] (O) [C@H] (N3C=NC4=C3N=C (C#CC5=CC=CC6=C5) N=C4NCCC7=CC (OC/C=C\CO6) =C (OC) C=C7) [C@H]1C2) =O

• Molecular Formula:

  C34H34N6O6

• Molecular Weight:

  622.67

• References & Citations:

  [1]Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and -Arrestin2 Signaling Preferences. ACS Pharmacol. Transl. Sci. 2023.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported