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A3AR agonist 2

CAT: 0804-HY-155184Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155184Size:1 Each
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Description
A3AR agonist 2 (Compound 19) a selective A3AR agonist (Ki: 22.1 nM) . A3AR agonist 2 stimulates β-arrestin2 recruitment, with EC50 value of 4.36 nM. A3AR agonist 2 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions[1]. A3AR agonist 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a3ar-agonist-2.html
Solubility
10 mM in DMSO
Smiles
CNC([C@]12[C@@H](O)[C@@H](O)[C@H](N3C=NC4=C3N=C(C#CC5=CC=CC6=C5)N=C4NCCC7=CC(OC/C=C\CO6)=C(OC)C=C7)[C@H]1C2)=O
Molecular Formula
C34H34N6O6
Molecular Weight
622.67
References & Citations
[1]Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and -Arrestin2 Signaling Preferences. ACS Pharmacol. Transl. Sci. 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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