A3AR agonist 2

• Description :

  A3AR agonist 2 (Compound 19) a selective A3AR agonist (Ki: 22.1 nM) . A3AR agonist 2 stimulates β-arrestin2 recruitment, with EC50 value of 4.36 nM. A3AR agonist 2 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, and other chronic conditions[1]. A3AR agonist 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/a3ar-agonist-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CNC([C@]12[C@@H](O)[C@@H](O)[C@H](N3C=NC4=C3N=C(C#CC5=CC=CC6=C5)N=C4NCCC7=CC(OC/C=C\CO6)=C(OC)C=C7)[C@H]1C2)=O

• Molecular Formula :

  C34H34N6O6

• Molecular Weight :

  622.67

• References & Citations :

  [1]Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and -Arrestin2 Signaling Preferences. ACS Pharmacol. Transl. Sci. 2023.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported