A3AR modulator 1

• Description :

  A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM) . A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [35S]GTPγS binding Emax[1].

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/a3ar-modulator-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCCC(C1=NC2=C(C3=C(N=C2NC4=CC=C(C=C4)I)C=CC=C3)N1)CCC

• Molecular Formula :

  C23H25IN4

• Molecular Weight :

  484.38

• References & Citations :

  [1]Lucas B Fallot, e al. Structure-Activity Studies of 1 H-Imidazo[4,5- c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. J Med Chem. 2022 Nov 24;65 (22) :15238-15262.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Adenosine A3 receptor (A3R)

• CAS Number :

  [2991693-62-8]