A3AR modulator 1

A3AR modulator 1

• CAS Number: 2991693-62-8
• UNSPSC Description: A3AR modulator 1 (MRS8054) is an orally active A3 adenosine receptor (A3AR) (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [35S]GTPγS binding Emax[1].
• Target Antigen: Adenosine Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/a3ar-modulator-1.html
• Solubility: 10 mM in DMSO
• Smiles: CCCC(C1=NC2=C(C3=C(N=C2NC4=CC=C(C=C4)I)C=CC=C3)N1)CCC
• Molecular Weight: 484.38
• References & Citations: [1]Lucas B Fallot, e al. Structure-Activity Studies of 1 H-Imidazo[4,5- c]quinolin-4-amine Derivatives as A3 Adenosine Receptor Positive Allosteric Modulators. J Med Chem. 2022 Nov 24;65(22):15238-15262.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported