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A3AR agonist 1

CAT: 0804-HY-155183Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155183Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A3AR agonist 1 (Compound 12) is an A3AR agonist (Ki: 25.8 nM) . A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC50 value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc[1].
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/a3ar-agonist-1.html
Solubility
10 mM in DMSO
Smiles
CNC([C@]12[C@@H](O)[C@@H](O)[C@H](N3C=NC4=C3N=C5N=C4NCCC6=CC(OCC/C=C/CCO5)=C(OC)C=C6)[C@H]1C2)=O
Molecular Formula
C28H34N6O6
Molecular Weight
550.61
References & Citations
[1]Dilip K. Tosh, et al. First Potent Macrocyclic A3 Adenosine Receptor Agonists Reveal G-Protein and -Arrestin2 Signaling Preferences. ACS Pharmacol. Transl. Sci. 2023, 6, 9, 1288?305.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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