A3AR antagonist 2

• Description :

  A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an Ki value of 4.54 nM[1].

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/a3ar-antagonist-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=NC2=NC=CC=C2N3C1=NN(C4=CC=C(OC)C=C4)C3=O)C5=CC=CC=C5

• Molecular Formula :

  C22H16N6O3

• Molecular Weight :

  412.40

• References & Citations :

  [1]Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand?Receptor Modeling Studies J. Med. Chem., 2009, 52 (8), pp 2407-2419|[2]Vittoria Colotta, et al. Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a New Scaffold To Develop Potent and Selective Human A3 Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies. J. Med. Chem. 2009, 52, 8, 2407-2419.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Adenosine A3 receptor (A3R)

• CAS Number :

  [1144161-05-6]